The entire book of jasher pdf

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1. Weapon balance changes: This is personally one change that I would love to see. Even if its once or twice a season weapon special, mod or behemoth weapon changes would be a great way to shake up the meta. Imagine a world where cruel riftstrike is a meta special. It doesn't have to be meta shaking changes something simple like reducing the cooldown on phalanx weapon rockets to make them a more usable weapon would be a nice refresher to the game and could encourage more people to use the weapon.
2. Make future events weapons easier or more worth the effort: lets be honest the silver sword is good but the grind is a massive put off. No one really wants to spend days of playtime to get a single weapon, but a simple fix could be to either to make the event weapons easier to get or just make each step of the quests give more rewards.
3. Reduce slayer path prices: I know just playing the game will give me all the resources I need to be able to get the slayer path upgrades, but I have nearly 500 hours in the game and i probably have around half of the slayer path upgrades. Its a small change but its a quality of life change that I'm sure a lot of the casual player base would much appreciate.
4. Leader board gauntlet rewards: Obviously we have trials leader board rewards such as the champions armour and weapon transmogs and something similar for gauntlet would be a good incentive for guilds to want to get higher in the gauntlet. A simple idea would be to make it like trials where there would be transmogs that are available to everyone for a certain amount of gauntlet coins and then have some reskinned transmogs for top 25 guilds that would cost more gauntlet coins or something similar.
5. A new weapon: This is one that has been asked for years and I'm sure that you have heard it 1 million times but its for good reason. A new weapon would be amazing for dauntless because its been years since a new weapon was released and a new weapon would be such an amazing thing because it would allow the community to be able to learn an entirely new weapon and master it.

Symptoms Of Bladder Cancer

• Pelvic discomfort
• Inability to urinate
• Inflammation of the feet
• Bone ache
• Weight reduction that occurs unintentionally

What Are Some Bladder Cancer Risk Factors?

• Age: As you get older, your chances of developing bladder cancer increase. Approximately 90% of those diagnosed are above the age of 55.
• Smoking: Smoking is one of the most significant risk factors. Smokers are at least four times more likely than non-smokers to develop bladder cancer. Tobacco includes carcinogenic agents (cancer-causing substances) and is the cause of half of all bladder cancers.
• Men are three to four times as likely than women to have bladder cancer.
• Drinking water containing arsenic has also been related to an increased risk of bladder cancer. The likelihood of being exposed to arsenic is determined by where you live and the source of your drinking water.
• The second leading cause of blood cancer is exposure to specific chemicals. Bladder cancer is increased by some industrial chemicals used in the dyeing, textile, paint, leather tanning, and printing industries. Bladder cancer has also been related to some naturally occurring compounds, aromatic amines, and herbal products including aristolochic acid.
• People who have had a family member diagnosed with bladder cancer are more likely to develop the disease themselves. Changes in genes such as GST and NAT, which are involved in the breakdown of some toxins, have also been linked to an increased risk of bladder cancer.
• Long-term urinary tract infections (UTIs), kidney and bladder stones, and using bladder catheters for a long time have all been associated to the development of chronic bladder infection.
• Chemotherapy and radiotherapy-induced secondary disease: Long-term treatment with chemotherapy medicines might irritate the bladder. Bladder cancer is more likely in people who have been treated with this medicine.
• People who are exposed to radiation near the pelvic region during cancer treatment, such as bowel cancer, are more likely to develop bladder cancer.
• Schistosomiasis, which is caused by a parasitic worm going into the bladder and is mostly found in Africa and the Middle East, is also a risk factor.

Bladder Cancer Treatment Cost In India

• Chemotherapy: Starting USD 270 per session (Indian Rupees Approx. 19,000)
• Surgery: Starting USD 2700 (Indian Rupees Approx. 1,90,000)
• Radiation Therapy: Starting USD 3,100 (Indian Rupees Approx. 2,20,000)
• Trans-Urethral Bladder Tumour Resection (TURBT): Starting USD 3,600 (Indian Rupees Approx. 2,50,000)

Diagnosis Of Bladder Cancer

• Urinalysis is a simple test that looks for blood and other chemicals in a urine sample. This test employs chemical dipsticks that change colour in the presence of chemicals such as glucose, red blood cells (RBCs), and so on.
• Urine cytology is the study of a urine sample under a microscope to look for pre-cancerous or malignant cells. For this procedure, the urologist inserts a cystoscope into the opening of the urethra and into the bladder to examine the inner lining of the organ. A camera and a lens are linked to a narrow tube, it is what is called a cystoscope. To make the procedure comfortable and soothing, the patient is usually given a local anaesthetic cream to apply to the urethra.
• Biopsy: If abnormalities are discovered during a cystoscopy, the patient will be given a biopsy operation termed "Transurethral Resection" of a bladder tumour (TURBT). The tumour (abnormal region) must be removed, and the area must subsequently be tested for malignancy. Because cancer often spreads to multiple areas, multiple samples are taken for testing to see if the cancer has migrated to surrounding bladder muscles.
• Imaging Scans: For a more exact image of the bladder, these scans allow the specialist to determine whether cancer has progressed to tissues near the bladder, urinary tract, neighbouring lymph nodes, or other organs. Imaging tests include the following:
• A dye is used in an X-ray treatment to show the kidneys, ureters, and bladder, as well as malignancies in the urinary tract. IVP (intravenous pyelogram):
  • Scanning using a CT scanner
  • Ultrasonics
  • The magnetic resonance imaging (MRI)
  • Scanning of the Bone (to check for spread to the bone)

India's Bladder Cancer Treatment Options

• Trans-Urethral Bladder Tumour Resection (TURBT): This procedure is used to treat and diagnose bladder tumours. During this procedure, a cystoscope (a small tube with a light and a camera) is introduced into the bladder through the urethra. A small wire loop is attached to the end of the cystoscope and is used to remove abnormal tissues or burn the tumour with a laser or high-energy electricity (fulguration). The patient is given local anaesthetic for TURBT. In the early stages of non-muscle invasive bladder cancer, this is the most usual treatment option.
• Cystectomy: The bladder is removed entirely or in part. When there is invasive cancer, this procedure is used.
• Radical Cystectomy entails the removal of the whole bladder as well as surrounding lymph nodes. When cancer has invaded the muscle walls and is large, this surgery is used. The prostate and seminal vesicles are the adjacent organs removed in males with this procedure. The uterus, fallopian tubes, ovaries, and a portion of the vagina are among the organs removed in women. The surgeon then creates a new path for the body's urine to flow through.
• A segmental cystectomy is also known as a partial cystectomy. Only a part of the bladder is removed, together with the area of the muscle layer that has been invaded by cancer. The most significant benefit of this operation is that the patient retains his or her bladder and can urinate regularly following recovery.
• Urinary Diversion: Reconstructive surgery is used to develop an alternative method of storing and transporting pee. Various types of surgeries may be performed depending on the medical situation and the patient's preference. The three types are as follows:
• Incontinent Diversion: The surgeon removes a section of the intestine and connects it to the ureters to create a conduit for urine to exit the body. As a result, urine flows from the stoma, a hole in the skin in front of the belly, through this passageway from the kidneys to the outside world. The urine comes out in little amounts and is collected in a small bag placed over the stoma. In this process, there is no control over the flow of urine.
• Continent Diversion: A portion of the small or large intestine is utilised to produce a pouch that serves as a urinary reservoir within the body, with one end of the pouch attached to the stoma. A valve is created in the pouch, allowing urine to be stored. This method appeals to the patient because it eliminates the necessity for an external bag. Urine can be evacuated from the stoma with the use of a catheter.
• Neobladder: This is a new procedure in which the surgeon creates a new bladder (Neobladder) from a section of the intestine and connects it to the urethra. This method restores urination by rerouting urine back into the urethra. As a result, the patient will usually pass pee.

• Intravesical Chemotherapy: This method is used to treat cancer in its early stages and involves injecting a chemotherapeutic agent directly into the bladder.
• Systemic Chemotherapy: For this treatment, the drugs are given as tablets or injected into a vein or muscle, where they enter the bloodstream and disseminate throughout the body.
• Radiation Therapy: This entails the use of high-energy x-rays to halt and destroy the growth of cancer cells. There are two types of radiotherapy:
• External Beam Radiation: This is the most popular type of radiation therapy, in which a system located outside the body is used to guide radiation directly to the tumour.
• Internal-Beam Radiation/Brachytherapy: This treatment uses radioactive implants, such as needles, seeds, or catheters, that can be put close or directly into the malignancy. Radiation therapy is typically used after surgery (TURBT) to kill any remaining cancer cells, as part of advanced-stage cancer pre-treatment, or to relieve symptoms like pain and bleeding caused by advanced bladder cancer.
• Biological therapy is also known as immunotherapy. This treatment is the administration of medicine to boost a person's immune system, allowing them to detect and battle cancer cells. It is necessary to employ compounds made by the body or in a laboratory to strengthen or target the immune system or restore function. The BCG vaccine is an example of biological agents used in immunotherapy after TURBT treatment. Other drugs utilised include atezolizumab, avelumab, and nivolumab. The drugs are given as intravenous (IV) infusions every 2 to 3 weeks.

1. N-Acetyl-Cysteine (NAC): 600-1800mg per day, divided in 1-3 doses. I use the NOW brand. NAC is an antioxidant that helps me tremendously in decluttering my head. I feel more 'empty' and I worry and overthink less. NAC is very famous also in OCD and limerence (unhealthy crushes) circles for reducing rumination. NAC balances dopamine and glutamate release, which is why it's also very effective for addictions.
2. Lithium orotate: 5-20mg per day, at night. I use the Swanson brand. Lithium orotate is a safe and benign version of the essential mineral lithium. Lithium has gotten a bad reputation because in 'regular' doses of 600-1800mg lithium carbonate, it has a lot of side effects. Lithium orotate is taken in doses that are magnitudes smaller than this, and as such the side effect profile is very positive and doesn't require blood tests. Out of all supplements I've ever tried (a lot), this microdose of lithium orotate has had the biggest positive impact on my emotion regulation and mental stability. It's enabled me to live a normal life. It partly works by raising serotonin levels, which HSPs are known to have less of. It also influences COMT, which is the enzyme that breaks down dopamine and (nor)epinephrine. People with a slow COMT are often referred to as 'Worriers' as opposed to 'Warriors'. Lithium speeds up COMT, which I feel makes the impact of stressful situations last a little shorter. I highly, highly recommend this supplement. Be sure to start with a low dose (there are 1 and 5mg pills available online) and work your way up slowly.
3. Magnesium l-threonate: 2000mg containing 144mg elemental magnesium, divided in 1 daily and 2 nightly doses. I use the NOW brand. Magnesium l-threonate is a novel version of magnesium that is able to get into the brain, where it calms the mind. It has been found to be helpful in the extinction of fears, and boosts the efficacy of cognitive therapy for anxiety. It has also helped my focus a ton. I have found that magnesium l-threonate increases my desire for social interaction, raises my overstimulation threshold, and calms my mind down. I have made great progress in tackling my social anxiety using it. Other forms of magnesium are also helpful, and much cheaper (like glycinate), but I've found that threonate is the only version that gives me consistent mental benefits.
4. Very Low Dose Abilify (VLDA): 1-2,5mg per day, in the morning. This one is thanks to my therapist. I'm generally anti-pharmaceuticals, but she suggested that an extremely low dose of aripiprazole (Abilify) is often prescribed to reduce Sensory Processing Sensitivity. In 'regular' doses of 15-40mg, Abilify is an atypical antipsychotic that mostly blocks the dopamine D2 receptor. However, in very low doses of 1-2.5mg, Abilify has an entirely different mode of action. It acts as a dopamine stabilizer, raising dopamine levels where they are low, and lowering them where they are excessively high. This means it's an effective mood stabilizer, works well against addictions, and raises my motivation and energy levels. In this microdose, I have experienced none of the side effects that could occur at regular levels. If you decide to try this, be sure to talk to your psychiatrist and be sure to start low and go slow. I built up my dose by breaking 2.5mg pills into quarters and slowly working my way up. I have found it tremendously beneficial.
5. Fish oil: two tablespoons daily. I use the Carlson brand. A good fish oil (Carlson or Nordic Naturals) has beneficial effects on dopamine, serotonin, and more. I have found it has helped tremendously with blue-sy feelings. I feel more positive and have more energy. It's a must, unless you eat fish multiple times per week.
6. L-theanine. 200-800mg daily, divided into 1-4 doses. L-theanine is very famous. People put it in their coffee to prevent overstimulation. I do the same, it helps me be clear-headed and productive, and as an HSP I am sensitive to caffeine and this helps with the jittery side effects. I also take it before bed for the deepest sleep ever. I never wake up when I take l-theanine.