Holman hunt the shadow of death

Gene therapy has to be one of the fastest-growing segments in modern medicine amid increased focus on developing life-changing therapies for cancer and diabetes.
Genprex Inc (NASDAQ: GNPX) is one of the few clinical stage companies offering exciting investment opportunities in a segment growing at a compound annual growth rate of 19.1%.
It is one of the few plays trading at highly discounted levels while developing therapies and technologies for treating a range of disorders, such as inherited diseases and cancers. Rather than treating patients with drugs or surgeries, Genprex is working on therapies that insert genes into a cell to cure various diseases caused by genetic variants. Gene therapies stand out partly because they are one-time events, although there might be additional dosages.
With the Gene therapy market expected to grow to $29.47 billion from $7.54 billion in 2022, there is every reason to be bullish about Genprex's growth metrics and long-term prospects.
Here are a few reasons why Genprex should be on your watchlist.
TOP GNPX HIGHLIGHTS
• GNPX stock is trading near a 52-week low with RSI near 46 - A strong bounce can happen ANYTIME
• Dawson James has a Buy rating on the stock and an average price target of $5.61 - representing over 500% upside potential from current levels.
• Genprex is home to some of the best technologies designed to administer disease-fighting genes most effectively.
• Genprex has made impressive strides in developing REQORSA, its novel treatment for lung cancer.
• With the Gene therapy market expected to grow to $29.47 billion from $7.54 billion in 2022, there is every reason to be bullish about Genprex's growth metrics and long-term prospects.
Robust Gene Therapy Technologies
Genprex (GNPX) is home to some of the best technologies designed to administer disease-fighting genes most effectively. As a result, its technologies have the potential to provide new breakthrough therapies for large patient populations struggling with cancer and diabetes.
Nanoparticle Delivery System is the first systemic gene therapy delivery platform that can be used to enclose plasmids that deliver tumor suppressor genes. It also administers encapsulated plasmids which are taken up by tumor cells and express any missing proteins in the tumor cells.
In addition, the company has REQORSA, a leading immunogen therapy drug for non-small cell lung cancer. The therapy is administered through the company's systemic gene therapy platform for cancer.
Finally, Genprex boasts of game-changing GPX-002, a diabetes gene therapy comprising a novel infusion process. It relies on an endoscope and adeno-associated virus vector to deliver Pdx1 and Mafia to the pancreas.
Lung Cancer Treatment
REQORSA is the company's lead candidate drug currently in clinical trials for the treatment of non-small cell lung cancer and small cell lung cancer. The novel treatment positions Genprex to be a key player in treating lung cancer, the leading cause of death worldwide. Lung cancer causes more deaths than colorectal, breast, liver and stomach cancer. With the limited benefit from current therapies, Genprex novel candidate drug has what it takes to address the unmet medical need, more so in lung cancer patients.
After successful clinical trials, the candidate drug has already received fast-track designation from the Food and Drug Administration. In a recent Acclaim-1 phase, ½ clinical trial REQORSA, combined with tagrisso(R) (osimertinib) for treating small cell lung cancer, was well tolerated with no dose-limiting toxicities. The Safety Review Committee has already approved continuation into phase 2 expansion. A combination of REQORSA and Osimertinib has already received Fast Track designation from the FDA for use in the Acclaim-1 patient population.
Genprex (GNPX) is already conducting preclinical research as it looks to explore REQORSA's potential use in other solid tumors. It is also exploring how other cancer-fighting genes can be used on its non-viral gene therapy platform.
Multidisciplinary Management Team
Genprex's (GNPX) long-term prospects are further affirmed by its multidisciplinary team of executives and advisors. The broad business experience in biotech and pharmaceutical that the team brings should allow the company to accelerate the development of its novel treatment for lung cancer and address the significant unmet medical need.
The management team boasts of highly experienced personnel as part of its scientific advisory board that reviews research and development activities and provides recommendations to accelerate the development of the moving treatment. There is also a clinical advisory board tasked with overseeing clinical trials to ensure they are up to board or approval by the FDA.
Why Genprex (GNPX) Stock is a Buy Now
Genprex (GNPX) is among the few gems in gene therapy trading at highly discounted levels. With a market cap of about $41 million, the company is highly undervalued, given the milestones made in developing revolutionary technologies for administering disease-fighting genes in the fight against cancer and diabetes.
In addition, the company has made impressive strides in developing REQORSA, its novel treatment for lung cancer. The treatment achieving fast-track designation from the FDA affirms how prospective the candidate therapy is in addressing one of the biggest unmet medical needs.
Strategists in Wall Street have already taken note of the company's long-term prospects, with Dawson James initiating coverage of the stock with a Buy rating. In addition, the stock boasts an average price target of $5.61, representing over 500% upside potential from current levels.
While insiders own about 4.5% of GNPX, their interests are perfectly aligned with that of investors. Likewise, institutions owning about 7.8% of the stock underscore the strong belief in the company's gene therapy pipeline.
In the near term, the investment community could elevate the value of GNPX closer to that of its peers.
If you need more info,
Then you can view a really detailed report out HERE.

Hello! 10th grade student in ontario. This essay is worth 30% percent of my grade and i want to do my best! Please tell me what you think and what you would rate it. I am writing this argumentatively using supportive opinion paragraphs made of subtopic-point-proof-analysis-conclusion method.
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Nature Versus Nurture
Nature versus nurture is a long-standing debate over the true determinant of how personality is formed and how the human mind works, with nature being the winning force, shaping the fabric of human disposition. The book And The Mountains Echoed, and the television shows Hannibal and Better Call Saul illustrate the following ideas: primal and intrinsic characteristics are unaffected by external influences; personalities cannot be inculcated in a person but are instead innate; people revert to their base instincts when pressed. These ideas prove that in the discussion of nature versus nurture, nature reigns supreme, wielding its power over the fundamental genetic traits that mold humanity and define the very essence of human existence.
To begin, primal intrinsic instincts are unaffected by external influences. Regardless of the strength of the influence or environment, a person’s true nature and hereditary traits will be impervious to change. A compelling example of this can be found in the television show Hannibal, whose title character is a brilliant psychiatrist and a cannibalistic psychopath (Hannibal). Hannibal began experiencing homicidal inclinations at a young age, indicating his nascent psychopathy, which fully manifested when he willfully ate his sister’s remains after her death ("Digestivo"). Despite later being adopted by his loving uncle, studying fine arts and medicine, and living the rest of his adolescence in the lap of luxury, Hannibal’s urges were ineffaceable, and he used his anatomical knowledge as a tool to kill and consume more people ("Oeuf"). Despite genuinely loving his sister and mourning her after her death, Hannibal could not deny himself his inherent psychopathic urges and consumed her. Though he eventually left his home to pursue his studies and escape growing suspicion from local authorities, changing careers from surgery to psychiatry and experiencing different environments, he remained unchanged and guiltlessly continued murdering and cannibalizing peers and strangers alike. Although Hannibal’s love for his sister was genuine and he was well cared for by his uncle, his surroundings and influences could not suppress his innate psychopathy and character, exemplifying the power that nature exerts over fundamental human traits.
Nature versus nurture is an enduring debate, argued by many famous scientists and philosophers in history - notably Plato and Descartes, who believed that behavior was inbred and organic to human structure. Correspondingly, it can be argued that personalities cannot be inculcated in a person but are innate. Human personalities are passed down through generations through genetics and are unshaken by outside pressures. This can be observed in the case of Pari in the novel And the Mountains Echoed. Pari was an Afghan-born girl who was adopted away from her village by a wealthy family and taken to France, all at a very young age (Hosseini 90). Pari’s adoptive mother was a rebellious, troubled, and romantic woman, as well as a talented poet; traits she tried to instill in Pari, who rejected the influence and grew into a humble and family-oriented individual, aligning with the characteristics also exhibited by her biological brother (Hosseini). Though Pari had no memory of her childhood in Afghanistan or of her birth family, she still developed personality traits similar to them due to their passing down through her genetic lineage, leading her to develop her identity and resist her adoptive mother’s attempts to alter it. Pari’s experience supports the claim that personalities resist external influences because they are formed from inherent and natural traits, which hold the most power over the formation of human temperament.
Finally, people revert to their base instincts when pressed. An individual’s base characteristics and natural traits will present themselves in moments of stress or when making snap decisions, often overriding learned behaviors and other external factors and influences. Jimmy "Slippin’ Jimmy" McGill, from Better Call Saul, is a perfect example of this: a clever scam artist turned corrupt criminal lawyer. Jimmy strived to be a law-abiding citizen and uphold a moral code (Better Call Saul) but often manipulated courts, clients, and evidence if he felt it necessary, resorting to immoral schemes and deception when pressed, as he learned to do during his time as a con artist ("Fall"). Jimmy’s instinctual responses to challenging situations voided his attempts to improve himself, instead proving his unchangeability to his loved ones, who correctly believed he could not overcome his nature. Jimmy’s inability to truly alter his innate instincts demonstrates the sheer strength of nature.
As evidenced in Hannibal’s, Pari’s, and Jimmy’s experiences, base characteristics are unaffected and unsuppressed by external influences, as are personalities, and these fundamental character traits always rise to the surface in a person when pressed, thereby proving that nature, thanks to its power over the underlying genetic features that shape people, overpowers external factors and reigns triumphant in the age-old debate between nature and nurture. Humanity is formed by the hands of nature, with biological factors predominantly molding human disposition and the way the human mind functions.
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WORKS CITED
Hannibal. Created by Bryan Fuller, NBC, 2013-2015.
“Digestivo”. Hannibal. Created by Bryan Fuller, NBC, 2013-2015.
“Oeuf”. Hannibal. Created by Bryan Fuller, NBC, 2013-2015.
Better Call Saul. Created by Vince Gilligan and Peter Gould, High Bridge Productions, 2015-2022.
“Fall”. Better Call Saul. Created by Vince Gilligan and Peter Gould, High Bridge Productions, 2015-2022.
Khaled Hosseini. And the Mountains Echoed. Bloomsbury Publishing Ltd, 2018.

Singles/ICYMI
If Not For Me - Demons
Revaira - When I‘m Gone
Code Orange - Grooming My Replacement + The Game
Moodring - WOULDYOUWAITFORME?
Within Destruction - Vengeance
Eighteen Visions - Rot of Humanity
Sylosis - Poison for the Lost
To Kill Achilles - Chemical Counterpart
Causality - Introspection
DVST - Opportunist feat Consvmer
thrown - guilt
Bilmuri - All Gas
Happy Hour - Mental Hellth
Fever 333 - $wing
Albums/EPs
Pupil Slicer - Blossom (Chaotic Hardcore/Mathcore)
Atlases - Between the Day & I (Post-Metal/Metalcore)
Queen Kona - All Hail EP (Metalcore)
Scarnival - The Hell Within (Melodic Death Metal/Metalcore)
Dethrxner - Taunt EP (Hardcore/Nu-Metalcore)
Writing The Future - Caught Between Heaven & Hell (Metalcore/Electronic)
American Nightmare - Dedicated to the Next World EP (Hardcore/Punk)
Shadowteeth - Liquid Sun EP (Progressive Metal/ Metalcore) out now
Semper Acerbus - The Heart and the Machine EP (Metalcore) out now
5pm Promise - Decentralise EP (Post-Hardcore/Alternative Rock) out now
Aeffect - Theory of Mind (Technical Death Metal)
Avenged Sevenfold - Life is but a Dream…
Don’t Sleep - See Change (Hardcore/Punk)
Brooklane - Stay Toxic EP (Pop-Punk)
Superlove - follow:noise (Alternative Rock/Electronic)
Title Holder - What Better Time (Punk-Rock)
Rancid - Tomorrow Never Comes (Punk-Rock)

I (34/f) have been having very disturbing dreams about my sisters ex-husband. For context, he (Jackson) is in his late 30s not much older than me and my sister (kiera) is 2 years younger than me. They’ve been divorced since 2016. Before the divorce, I used to sleep at their house for a night or two whenever I would visit. He would usually be out of the country for work so Kiera and I had the house to ourselves most of the time. When I first met him, I disliked him right away and he didn’t like me either. That was the first time that’s ever happened to me so intensely. He would barely say a word to me when he was around and made little to no eye contact. He was very judgmental. I could tell he looked down on me bc I was still attending college and was living a life that would be typical of a college student instead of having a career. I was 24 at the time and I was insecure about that. I really disliked him mostly for how he treated my mother. He would ignore her calls and texts when she would wish him happy birthday or congratulate him for a promotion or just saying hello..whatever. Whenever we would visit he would go in the bedroom and not come out. Whenever we would leave I would get a text from my sister apologizing but then saying that me or my mother did something he didn’t like for example I didn’t ask him or my sister if I could have a glass from the cabinet before getting a drink. “I just helped myself.” Our family doesn’t ask for permission for things like that so I didn’t know that’s how it was in my sisters home. Anyway, they were together for a year and then she was pregnant, they moved into a bigger house and 9 months later, my nephew was born. One day I’m hanging out with my friends and I get a text. It’s from Jackson. He asks if he could call me. I was worried about Keira so I say yes. He calls me and says he’s been drinking. He says he on the front porch and Keira is asleep. He tells me he thinks she’s drinking and hiding wine bottles from him and he has to leave the country so now he’s worried. He said would feel better if I were to stay at their house for a week while he’s away and watch her. I said of course and I went to the house. He left before I arrived and my sister was happy to see me and of course I was happy to see her and my baby nephew but at the same time I was scared that she wasn’t doing well. Turns out she was suffering from postpartum and she had been drinking and taking anxiety medication. I was very worried and I texted Jackson saying she’s not doing well and she needs him there and yes she is drinking. He comes home. When he gets back, he says I’m welcome to stay as long as I want and is acting completely different towards me. He is nice, generous, and protective even. The 3 of us ended up drinking wine after she put the baby down bc it was Valentine’s Day and I had just got into a fight with my ex boyfriend. I’m not proud of drinking with her when she had a problem but I was also very immature and I was going through a lot of trauma at the time. I figured if Jackson were to talk to her about the drinking and lay down the law, I would be there to be a support to her and help with the baby while she sought help. So this night Keira became very intoxicated very quickly and went to bed. Jaxson helped her up the stairs and I figured they were going to bed so I started to clean up and turned the lights off. I’m in the kitchen on my phone about to head to the couch a few feet away to lay down. That’s where I slept when I was there bc the guest room wasn’t done yet. Anyway, I hear Jackson walking down the stairs and I figured he’s just getting water or something and heading back up. He ends up getting a drink and standing in the kitchen and starts talking to me in the dark with just the lights of the television and my phone. He asked me if Keira cheated on him. I said of course not. He asked again. Then he asks me if my sister is a lesbian. I laughed and said no.. and I said I’m going to bed. He’s getting closer to me and he’s smirking now. He’s very close to me and he asks me if she ever told me about his penis and he leaned in almost touching my face with his. I said no we don’t talk about things like that with each other. He proceeded to ask me something. Else inappropriate and that’s when I heard Keira who was at the bottom of stairs say “my own sister!” She was very upset and still very drunk. Jackson took het back upstairs and I figured we’ll talk in the morning when she’s sober and I’ll let her know nothing happened but he was asking me weird questions. I get ready for bed and go to the couch. Some time goes by and I’m still awake. Jackson comes back down again and sits on the couch next to me. He tried to continue with the weird questioning about what I know about him and their sex life and his penis. I was admittedly laughing it off in the beginning in the kitchen but now I’m just annoyed and I tell him I’m tired and I need to sleep. He retreats back upstairs. I go to sleep and I wake up to him staring at me from the chair in the living room. I’m in and out of sleep but I could hear him shushing the dog and baby telling them to let me sleep. Nobody spoke about that night. Jackson continued to be nice to me and my sister was acting like nothing happened. Cut to the divorce. My sister had been in a dark place. She found out he was cheating on her and he divorced her and left her and my nephew to go be with this new girl in California. One day Keira was having a particularly bad day and she accused me of sleeping with Jackson. She claimed she saw it. I told her that he was very close to me and the lights were off but nothing like that happened. She was just getting angrier and angrier at me each time I would tell her a detail. I felt like I did something wrong. She ended up chasing me trying to punch me. I hid in a room and she was banging on the door for me to come out. The next month, on thanksgiving she got drunk while I baking the Turkey and she attacked me. I had a black eye and bloody nose. For years she would tell people that I slept with her husband and that I’m disgusting. Now, I have dreams that he’s inside me fucking me really hard like an animal and exploding inside me. The dreams always start off with me laying on that couch asleep and him touching himself. Then the atmosphere changes. The last dream I had I walked into the forest and he was hunting. He killed a deer and then started slicing it open and spilling its guts all over. He’s covered in blood and he spots me. I walk to a little shed and I am completely naked. He comes in bends me over getting blood on my back and ass. He pulls down his pants and fucks me from behind I feel him twitching inside me so I start to tighten my grip and he cums. Why is this happening? Is it possible that I did sleep with him and have absolutely no recollection of it? I really don’t think so but these dreams happen every so often and it’s honestly gross and I end up feeling sick with myself.

TL;DR: I believe Second Dinner forgot about existing cards and core concepts card game balancing while designing High Evolutionary. This, combined with the card acquisition system in Snap, set the game on the slippery slope of becoming pay-to-win. I recommend one change to the card to fix this: if High Evo is in your deck, no-ability cards get +1 cost. Details on why are at the end. Hi Ben, from one Blizzard alumni to another!
The actual post
Hi everyone, long time player first time poster. I wanted to breakdown why High Evolutionary is Pay-to-Win, from the perspective of game design, card game balancing & collectible acquisition systems. Who am I? I am a video game analyst with more than a decade of experience in the industry in top companies.
Foreword: I am not against a company designing a game to be P2W, I am also not going to tell anyone not to spend money because everybody is free to do whatever they want (although I will not be spending any more money myself). The reason I am writing this is: Second Dinner unintentionally made the game P2W, which speaks to the talent of their designers and in turn, the longevity of the game.
Vanilla Cards In card games, vanilla cards are when the card has no additional effect and the power of them is just the numbers on the card. In Snap, this is the cost and the power of the card. These vanilla cards are balanced around the mana/energy curve, and usually they get a higher powecost ratio compared to cards that do have other effects. Again, in Snap, this is represented well by the no-ability cards, (e.g. Thing, Abomination) while same cost cards either have either lower power and an upside, or higher power and a downside. High Evolutionary brings an upside to these cards with no in-game cost.
Power Creep The vanilla cards are almost always present in the early days of card games. However as time goes on, the card pool expands and these cards usually fall behind in power and in turn, usage. There are many ways to solve this problem, and I don't believe Snap currently has this problem as the game is comparatively recent. The addition of High Evo is expediting the power creep to a power trot for no reason.
Card Acquisition Among the many systems available in collectible card games, I would argue Snap is one of the slowest in terms of players getting new cards. The ability to target cards through collector's tokens is actually worse than being it entirely random, because these tokens are entirely separate from the size of the players' collection. Second Dinner remedied this somewhat with their changes over time, but the problem still persists that really powerful cards are much more accessible to paying players due to the Series 4/5 drop rates and Collector's tokens acquisition rates.
Why is High Evo P2W? Based on the information above, consider how you might make Vanilla cards more powerful, and enable an archetype of using them. Take Patriot, the other vanilla-enabler: - Patriot - Benefit: - Adds 2 power to no ability cards. - Drawbacks: - Has only 1 power - Needs to be drawn - Needs to be played - Has a cap / narrow interval of power it can grant to a lane: between 0-8.
Now consider High Evo: - High Evolutionary - Benefit: - "Unlocks" the abilities of no ability cards - Does not need to be drawn - Does not need to be played - Has 4 power - Has a super high ceiling of power it can grant to a lane - Drawbacks: - Fills up a slot in your deck(?)
We can already see on paper how this card is so much better in enabling vanilla cards. If you want to have a vanilla-card archetype, there is no reason to use Patriot over High Evo. To make things worse, here are the second layer of benefits: - High Evo abilities require floating energy, and there are a lot of cards that benefit from floating energy already (Sunspot, She-Hulk) - The counterplay to a High Evo ability is... not playing cards - There is no player counter to High Evo itself - it can't be destroyed, dis-Enchanted, etc. - Only 3 cards exist that can counter some (not all) of these benefits: Luke Cage, Valkyrie & Shadow King
When all of this is combined, currently High Evo is a "I win" card with minimal strategy or skill required with no counterplay. So what is preventing everybody from playing him? The 6000 token cost of acquiring him. For a F2P player that takes a ton of active play time, or you just purchase the tokens, either directly or through Collection Level boosts.
Why I think Second Dinner did not intend it to be P2W There are two that makes me believe SD did not think the design through when making High Evo. - Reason 1: Floating Mana as a "drawback" while having cards that benefit from floating mana, and locations that change costs or energy. - Reason 2: The powecost ratio of vanilla cards being higher than the curve. If these two were considered, it was an objectively bad design choice. If one or both of these were forgotten, I am very sorry to say it is incompetence; especially the second one. I don't want to read malicious intent, that is why I say it is unintentional.
So how can this be fixed? Remove High Evo, go back to the drawing board. Realistically though, here is my proposal: - If High Evo is in your deck, no-ability cards get +1 cost. This adds a drawback to the card, balances the powecost ratio, and require additional cards in the deck or relying on locations for playing that 20 power Hulk.
Thank you for reading. Just to pre-empt the obvious question: I am not using High Evo, because I do not have the tokens to unlock it. Even if I did have him, I would likely not use it as I don't like my win condition to be "opponent doesn't draw Luke Cage".

Gene therapy has to be one of the fastest-growing segments in modern medicine amid increased focus on developing life-changing therapies for cancer and diabetes.
Genprex Inc (NASDAQ: GNPX) is one of the few clinical stage companies offering exciting investment opportunities in a segment growing at a compound annual growth rate of 19.1%. It is one of the few plays trading at highly discounted levels while developing therapies and technologies for treating a range of disorders, such as inherited diseases and cancers. Rather than treating patients with drugs or surgeries, Genprex is working on therapies that insert genes into a cell to cure various diseases caused by genetic variants. Gene therapies stand out partly because they are one-time events, although there might be additional dosages. With the Gene therapy market expected to grow to $29.47 billion from $7.54 billion in 2022, there is every reason to be bullish about Genprex's growth metrics and long-term prospects. Here are a few reasons why Genprex should be on your watchlist. TOP GNPX HIGHLIGHTS • GNPX stock is trading near a 52-week low with RSI near 46 - A strong bounce can happen ANYTIME • Dawson James has a Buy rating on the stock and an average price target of $5.61 - representing over 500% upside potential from current levels. • Genprex is home to some of the best technologies designed to administer disease-fighting genes most effectively. • Genprex has made impressive strides in developing REQORSA, its novel treatment for lung cancer. • With the Gene therapy market expected to grow to $29.47 billion from $7.54 billion in 2022, there is every reason to be bullish about Genprex's growth metrics and long-term prospects. Robust Gene Therapy Technologies Genprex (GNPX) is home to some of the best technologies designed to administer disease-fighting genes most effectively. As a result, its technologies have the potential to provide new breakthrough therapies for large patient populations struggling with cancer and diabetes. Nanoparticle Delivery System is the first systemic gene therapy delivery platform that can be used to enclose plasmids that deliver tumor suppressor genes. It also administers encapsulated plasmids which are taken up by tumor cells and express any missing proteins in the tumor cells. In addition, the company has REQORSA, a leading immunogen therapy drug for non-small cell lung cancer. The therapy is administered through the company's systemic gene therapy platform for cancer. Finally, Genprex boasts of game-changing GPX-002, a diabetes gene therapy comprising a novel infusion process. It relies on an endoscope and adeno-associated virus vector to deliver Pdx1 and Mafia to the pancreas. Lung Cancer Treatment REQORSA is the company's lead candidate drug currently in clinical trials for the treatment of non-small cell lung cancer and small cell lung cancer. The novel treatment positions Genprex to be a key player in treating lung cancer, the leading cause of death worldwide. Lung cancer causes more deaths than colorectal, breast, liver and stomach cancer. With the limited benefit from current therapies, Genprex novel candidate drug has what it takes to address the unmet medical need, more so in lung cancer patients. After successful clinical trials, the candidate drug has already received fast-track designation from the Food and Drug Administration. In a recent Acclaim-1 phase, ½ clinical trial REQORSA, combined with tagrisso(R) (osimertinib) for treating small cell lung cancer, was well tolerated with no dose-limiting toxicities. The Safety Review Committee has already approved continuation into phase 2 expansion. A combination of REQORSA and Osimertinib has already received Fast Track designation from the FDA for use in the Acclaim-1 patient population. Genprex (GNPX) is already conducting preclinical research as it looks to explore REQORSA's potential use in other solid tumors. It is also exploring how other cancer-fighting genes can be used on its non-viral gene therapy platform. Multidisciplinary Management Team Genprex's (GNPX) long-term prospects are further affirmed by its multidisciplinary team of executives and advisors. The broad business experience in biotech and pharmaceutical that the team brings should allow the company to accelerate the development of its novel treatment for lung cancer and address the significant unmet medical need. The management team boasts of highly experienced personnel as part of its scientific advisory board that reviews research and development activities and provides recommendations to accelerate the development of the moving treatment. There is also a clinical advisory board tasked with overseeing clinical trials to ensure they are up to board or approval by the FDA. Why Genprex (GNPX) Stock is a Buy Now Genprex (GNPX) is among the few gems in gene therapy trading at highly discounted levels. With a market cap of about $41 million, the company is highly undervalued, given the milestones made in developing revolutionary technologies for administering disease-fighting genes in the fight against cancer and diabetes. In addition, the company has made impressive strides in developing REQORSA, its novel treatment for lung cancer. The treatment achieving fast-track designation from the FDA affirms how prospective the candidate therapy is in addressing one of the biggest unmet medical needs. Strategists in Wall Street have already taken note of the company's long-term prospects, with Dawson Jamesinitiating coverage of the stock with a Buy rating. In addition, the stock boasts an average price target of $5.61, representing over 500% upside potential from current levels. While insiders own about 4.5% of GNPX, their interests are perfectly aligned with that of investors. Likewise, institutions owning about 7.8% of the stock underscore the strong belief in the company's gene therapy pipeline. In the near term, the investment community could elevate the value of GNPX closer to that of its peers. If you need more info, Then you can view a really detailed report out HERE.

Last night, while filming my daughter's 7th grade band concert, I came to the realization that I need a better (camera) tripod for the camera stuff I want to do. In town and in the woods.
Small, fast, stable, quiet (hunting, shooting, and shooting video).
Less than $200-ish budget.
But here's the catch: it can't be hunting/shooting branded due to who's paying me back for it. They aren't super into the idea of guns, and I'm not doing this entirely sneaky because I WILL use it for photography/filming....
​
Whatchoo got?

What is the death of Jesus in our body?
The key to understanding this verse is through contrast as a literary device.
2 Corinthians 4:

7 But we have this treasure in jars of clay to show that this all-surpassing power is from God and not from us.

Jars of clay symbolize our frail bodies.

8 We are hard pressed on every side, but not crushed; perplexed, but not in despair; 9 persecuted, but not abandoned; struck down, but not destroyed.

These are examples of the sufferings of Jesus or the death of Jesus. Paul carried or experienced these in his body.

10 We always carry around in our body the death of Jesus, so that the life of Jesus may also be revealed in our body.

Here in one verse, we have the contrast between the death and life of Jesus in our body. This is the theme of the whole chapter.

11 For we who are alive are always being given over to death for Jesus’ sake, so that his life may also be revealed in our mortal body.

Again the bad news/good news contrast.

12 So then, death is at work in us, but life is at work in you.
16 Therefore we do not lose heart. Though outwardly we are wasting away, yet inwardly we are being renewed day by day.

Finally,

18 So we fix our eyes not on what is seen, but on what is unseen, since what is seen is temporary, but what is unseen is eternal.

The whole chapter is filled with contrasts between the death and the life of Jesus, ie, the outward-seen sufferings vs the inward-unseen glory in our body.
How to experience it?
It's a daily affair as we yield our bodies to obey God. Matthew 16:

24 Then Jesus said to his disciples, "Whoever wants to be my disciple must deny themselves and take up their cross and follow me.

I have the full Wind Waker and Zelda 1 sets which I would like to upgrade using the Great Fairy, but each upgrade requires one star fragment and a bunch of gems (rubies for Armor of the Hero, Opals for Armor of the Wind). The gems are easy enough to acquire, just poke around in caves in the Death Mountain region, but the star fragments are the tricky part. I know that one spawns each night between 12 and 5am, but I don’t always see them spawn. Is there perhaps a part of the map I could keep going to at night where they will be easy to spot and get to? I really should have abused the item dupe glitch while I had the chance.

I just published this one today. Will share it here with you guys. In our pursuit of personal growth and self-discovery, we often come across advice on self-validation, self-love, and trusting ourselves. However, the process of validating our own worth can feel like an enigmatic puzzle. We may find ourselves asking, “Sure, I want to validate myself, but how do I actually do it?” While our logical minds understand the concept, our instinctual response may differ. The truth is, certain crucial elements like unconditional love and self-esteem are typically nurtured during our upbringing. For those of us who come from dysfunctional families, where a parent consistently undermined our character and self-esteem, embracing self-validation may feel foreign. It’s as if our innate wiring lacks the capacity to naturally accept and validate ourselves. This struggle is even more pronounced for individuals who have endured a lifetime of bullying and invalidation. When we repeatedly hear that something is fundamentally wrong with us, that our emotions are abnormal, and our aspirations don’t align with societal expectations, self-validation can seem empty.
Let’s face it—self-validation is not a simple switch we can flip. It’s a complex process that requires self-reflection and awareness. Although we may intellectually grasp the importance of validating ourselves, our bodies and emotions often tell a different story.
Getting to Know Your Inner Saboteur
Understanding the Inner saboteur
Deep within each of us resides an inner saboteur—a whispering voice that resists change and clings to the familiar. It’s a shared aspect of the human experience, ingrained in our collective unconscious. We all recognize emotions like anger, fear, sadness, and joy. Likewise, we’ve all encountered this inner saboteur, though it doesn’t manifest as a distinct, loud voice. Instead, its presence is subtle, exerting a gentle tug in our actions and decisions.
Sometimes, detecting the inner saboteur is straightforward—choosing between an apple and a bag of chips, for example. But at other times, it hides in the shadows, evading our conscious awareness. It reveals itself through micro pulls—those subtle impulses we feel with each choice we make. It may manifest as the fear of expressing our true feelings as we fear what will happen to us when we reveal our true selves. It may manifest as a fear that holds us back from sharing something that we have created, or starting a business out of fear of failure, or it may manifest as the fear of the unknown preventing us from leaving a toxic relationship. The inner saboteur exerts its influence in various areas of our lives.
Understanding this inner saboteur is pivotal on our journey toward self-validation. It begins with recognizing that doubts and fears are universal experiences. We are not alone in navigating the internal struggle between comfort and growth. By acknowledging our shared humanity, we can begin dismantling the influence of the inner saboteur.
Pushing Past the Inner Saboteur
Beware: The inner saboteur will always make its presence known when you stand at the crossroads between empowering yourself and surrendering to familiar old habits. Sometimes, it sneaks in subtly, like a whisper in the wind. Other times, it roars like a thunderstorm, demanding your attention. Regardless of its form, the inner saboteur exerts a powerful influence on your decisions as you strive for personal growth. It’s essential to develop the skill of spotting its sneaky tactics deep within yourself, especially in those small moments when you make choices – the simple yes or no moments.
The inner saboteur’s pull can sometimes feel immense, like an enormous boulder blocking your path. It manifests as fear, fatigue, hopelessness, or an overwhelming weight that seems impossible to shed. But here’s the thrilling part: every time you consciously defy that negative tug of the inner saboteur, no matter how seemingly insignificant the action, you are actively building your self-esteem and validating your authentic self. It could be as effortless as stepping outside to bask in the warm sunlight or summoning the courage to express your thoughts and let your voice resound. These seemingly small acts hold incredible power. They serve as reminders of your worth and fortify your self-esteem.
By fearlessly confronting the backward pull within yourself, you embark on a transformative journey of self-validation. Granted, it won’t always be a leisurely stroll through the park. There will be uphill battles and moments where the path seems treacherous. But with each step you take, defying the grip of the inner saboteur, you affirm your inherent value and nurture your self-validation. Read more: https://artflorentyna.com/whats-the-deal-with-self-validation-how-do-i-learn-to-validate-myself/

Hey everyone. I'm stuck in a bit of a loop with RimWorld. I'll throw together a nice modlist, make sure it all works, do some light ideology planning in advance, and then just not play. I always procrastinate and put it off, and sometimes I get stressed out over the process of just creating the ideology regardless.
Even picking a crash sight can stress me out for some reason, and I doing get it. I love this game to death but it's like I have allergic reaction to getting started.
Does anyone have some tips on how to get over this issue?

This is a letter I wanted to send myself around half a year ago but didn't maybe because of what a bad place I was in (and still am), maybe I just needed to get some of the things out of my system. Today I found it and it reignited some things in me, and I wrote some more words about what is currently happening to me. I changed the names and some other things to remain anonymous. It's long and all over the place and I don't expect anyone to read it all honestly.
TRIGGER WARNING: Suicidal ideation, Suicide, Depression, Recklessness, Rejection
As before, I wonder what's going on in your life right now, because, honestly, I don't even feel like writing this letter at this point. Things are really bad, and today I have a good enough day to write something up but I don't feel well at all, and it doesn't seem like things will get better, if ever. Part of me knows that things always change and there's a chance that they will change for the better, but from my experience it doesn't usually work out, I seem to be switching from one issue to another, be it writing a thesis, finding a job, or my current state. I really can't seem to catch a break and for once be at least somewhat happy and satisfied with where I'm at in life.
I'm gonna tell a little bit about my situation and refer to some of the things you said in your email. Most of it will be about my "relationship" with Amy, and how much it affected me mentally.
I moved in with Amy and things are bad in ways I can't even describe. First thing is that over the beginning of the last year I fell in love with her and really, badly wanted to matter anything to her and be important to her, and for her to show that somehow for me. We went together on a trip to mountains and generally spend more time together than ever before. I really felt the chemistry between us, i thought we got a long really well. We talked at the fireplace party and she said she's too fucked up to date me, and that she would never do this to me. Since I moved in with her as a flatmate there were some things that bugged me about the way she is, like careless about a lot of things (mainly her safety and well being), horribly under eating in the name of some fucked up "diet", not listening to my guidance about most things, like not taking breaks at the gym, and other minor things that really bugged me and kinda felt conflicting because she doesn't seems childish, in fact quite the opposite, but some of those behaviours certainly felt like that at the time. But generally things were good, at least most of the time, we spent time together, went to gym, watched shows, threw a few parties etc.
As the time went on, things got worse, and I don't even remember every bad situation that happened over the last 5 months. Some early days she cried a lot, but it's this kind of stiff hopeless cry that really gets me. She doesn't feel emotional, she feels empty, her eyes are really scary sometimes... One day she got really drunk, I think it was an anniversary of her best friends passing, I was really anxious, because she didn't seem like she was controlling herself at all, and I don't know, seeing people just empty, hopeless, out of control, careless and drowning themselves in alcohol ALONE just affects me in a really bad way mentally. When we drove the next day to get her a bookstand (which she was really obsessed with getting this exact day) she was acting really manic and on the edge, I was so nervous that I shook her one time when she said something especially deranged (idea of driving with the complete bookshelf in the public commute), I don't know the last time I felt so much out of control of the situation and shaken, even though the whole situation is seemingly so fucking innocent. One day she threw away a line about how it's so stupid that suicide is a sin. We complain a lot about our lives and make dark humor jokes in our group, and yeah, there is always something real beneath them, I sometimes do have dark thoughts, and I feel like I have a lot of issues as well, but this is all heavy stuff that I wouldn't talk about freely and lightheartedly. I didn't thought then how serious she was, well I kinda did, because I asked her the next day about this, and she laughed saying "Are you serious right now? xD" And she said "Yes, of course I was serious". Before that she talked how she was so tired she was barely able to drive and see other cars, which worried me so much that I can't even describe it, and she didn't say it in a worried tone, just like she wanted to brag or something, I don't know why (she does that A LOT). And I don't know, but it was REALLY traumatic for me to hear her say those things like this, I couldn't sleep for days after this, I was in an especially bad place then. She said she first was going to do it when she was a teen, then once her mother dies, and right now since she knows it's a sin and she wants to see her family and friends she has to live to 50, thats how long she expects to live without killing herself. I said that she still has people here, do we not matter to her at all?, and she said that in the afterlife she has more of them. I said that doesn't she care anything about her health?, because she do goes to doctors and stuff, and she said she only does so because of her mother, she never went to a doctor because she wanted to. She said that she doesn't understand how atheists don't kill themselves immediately. She said it all without blinking an eye about how fucked up what she's saying is, it wasn't like confessing, more like explaining basic facts, and that's the thing that I think fucked me up the most, because if I were to say those things I would be shaking and having difficulties with every word, not throwing this stuff this carelessly.
I am writing wild scenarios in my head about how fucked up things she did in her past, in the parties etc. and they make me really anxious and depressed that she's like this and not much more innocent as I usually pictured her (and still sometimes do, because she's not acting toxic or deranged 100% of the time, she actually shows a lot of care for certain things, she loves every kid and animal etc., she never even smoked a cigarette), because she never seemed so much like a typical club party girl that gets into trouble a lot, well I knew she partied and drunk a lot, but she always seemed kinda different from that. Most of the time she's not like that, she can behave with a lot of compassion most certain situations. She talks about all the speeding tickets she got (and got out of by sweet talking the policemen), she texts all the time while driving, she admits to driving recklessly when alone, she lies to her mother all the time about how well mentally she is, how much she's drinking, like she were silently going on all fours between bedroom and bathroom bc she was so drunk, sometimes she even lies about having passengers when driving to the city we live in because she's so unwell she drives alone and makes stops along the way to make it, she lies about how long it took for her to drive. Sometimes I feel like everything is fake because of some of these things, like I am loosing the touch with reality.
One time we drove back to our hometown, and like halfway through she started to get really sleepy, I could see by the corner of my eye that her head was going down for a fraction of a second. I wanted to switch to drive, but she was having none of it, saying that she already planned to drive home herself and if she planned it then it will happen. I started to get really anxious and frantically started to think of the ways to do something, I stupidly suggested that I will drive my car after her once we get to my home, and she said "You really ARE fucked up xD", because she would still be inside her car and how that would help? And I know it wouldn't, but I panically tried to find something, that's just something that I came up with on the spot. I just told her to text me immediately when she gets home (and she did), but the whole situation was just so fucking stressful for me, I even then told my mother about what's happening but without darker details.
She seems to have a problem wich alcohol, although certain situations can prevent her from drinking extensively, like seeing the kids in school the next day. It's kind of scary how much she can drink and then be sober the next day.
One time she was on her period (they get really bad for her) and she wanted to drink some alcohol because of the weekend, but she was on her first week of antidepressants and all those things caused me not to go to my friends and stay with her to look after, she became really tired after a while, she was barely staying on her feet, when she went to take a shower before bed I asked her to not lock the door and she didn't. I went to clean the dishes, and I think I heard something but I didn't pay attention or anything, but later she was in bed and clearly trying to hide from me that she collapsed under the shower. She was okay, but the fact that she didn't want to admit it to me made me really anxious and depressed. She was so out of energy that I had to hold her the water bottle to drink from. I felt so bad, I don't think I could sleep that night.
She doesn't let me drive because once I drove with her when being really nervous and weren't like the best at it, it kinda angers me because it's double standard as fuck, not letting me drive when I'm nervous, but driving when you're almost sleeping. And I don't consider myself a bad driver, apart from once loosing control when going to friends wedding I have never have an accident. She also gets really mad if I'm going to drive after drinking single beer and waiting like 4 hours after it, and that's NOTHING compared to the things she does.
Sometimes I'm hesitant to tell her some of the things I think, partly because it't pointless, and partly because her response would just make me more triggered, angry, anxious and depressed.
Sometimes I don't know what to do, telling anyone about those things (like her mother) seems like breaking her trust, and those are personal things that I really shouldn't tell my friends about, hence I tell them to my therapist.
What's scary and fucked up is that depression is not only hopelessness, sadness and lack of energy, but for some people also being mad about everything, saying really hurtful things to people that love you, hating on and judging literally everyone, becoming really sickly, strongly obsessed about something, behaving carelessly and recklessly. And every attempt at trying to address those things is responded with some hateful, poisonous comments or "I'm just like that", one time I said to her that she should care less about something, and she responded with a lot of hate that I should just stop "shaking my hands when I'm nervous, can I do that? can I?" I feel so fucking bad sometimes, because part of me wants to scream into her face about the things she does, and at the same time:
I know that it's an illness, and I don't know if that would be bad of me to be angry at her about anything
I'm worried about things she would say to me back, she sometimes seems to revel in hurting people emotionally or at least being really good at it and constantly looking for topics when arguing with someone, and I'm really fragile, sensitive and easy to hurt, for some reason especially to things she says to me
I don't feel like I can have any influence on her actions, although she does comment a lot of the time that other people do, like Monika, Magda, Paweł etc. so sometimes I feel like it contradicts itself, although she does say that she needs to be controlled in some way to do what it said, like being yelled at or being put in the position with no choice, and I don't want to be like that and I don't think I have the strength of character to be like that, and never will
She sends a lot of memes about depression to our group chat, and I personally don't think they're helpful, at least for me, I'm not feeling like someone is going through the same thing as me and it helps, it's more like everyone is trying to drag each other down, some of those memes are as hopeless as you can get, making fun of therapy and psychiatrists, never having any happiness (dementors can't do anything to you), missing yourself and thinking its too late now to regain it, generally memes about not being a human anymore and never being again etc., being put into a mental hospital if you tell your therapist everything, about hating and despising other people. There's this friend that she says is way worse than her, and that he doesn't even want help unlike her, that he's so used to it he almost likes it, I honestly don't know if that doesn't also affect her. One time we drove to our hometown, 5 of us with him and a few others, and they were talking about suicide, and some other friend said this cliche line about suicide being the most egotistical thing a person can do, and even though he was quiet the whole ride he just said "Yeah, right" from the back. I don't know, I guess it depends on the person, but for me surrounding myself with this topics would make me feel worse and not understood. She also has a lot of kids in school with mental issues, she has a kid who is supposed to be after a suicide attempt (that's also one of the things that froze my heart, when she said that she knows he and his parents are bullshitting because he would be put to the hospital for 3 months, but how would she know that?), or generally kids that are on SSRIs and that one time kid told her justifying himself that he took the double dose of antidepressants and she was holding herself not to say "me too!". They had a movie night and they played UNO, and she said that out the 3 kids she played with, all of them were in a psychiatric hospital.
One time at a party in front of everyone she said she thought about jumping out of a window, but being crippled her mom would have to deal with that so she wouldn't do it like that. Other time she said she changes the mind when she loses the energy, she would try to hang herself but would become tired and not do it. Once also we talked about unrelated topic, and I said as a trivia that dead bodies can produce sounds like exhaling, and she said she knows that because she know a lot about dead bodies, and she reads a lot about that... Once she said that she doesn't understand that atheists don't immediately kill themselves when someone close to them dies. Once she said something about there not being anything left of her inside. Once she said that her mother was worried she would be locked up in a psychiatric hospital, but she had to assure her that she knows how to mask everything, and she's not dangerous to others so that wouldn't happen.
Am I too innocent for these topics? Sometimes I feel like a kid listening to adults, and that I don't know and don't understand them and I feel small and worthless.
I think there are a lot of different ways to direct that recklessness and negativity through things like exercise, media escapism, music etc. and not things like hard partying, drugs/alcohol, reckless driving, acting angry etc.
I think that deeply believing that chemical imbalance is the cause of depression is very hurtful, because it's not completely proven and might turn some people off from forms of treatment that could potentially help them.
Escapism is a big thing for me, and I think that it helped me cope with a lot of things. Books, movies, music, I spend a lot of time looking for new music and artists.
I'm becoming very nosy and kinda controlling around her (well not actually controlling cause that's impossible with her, but just very nosy), I want to eardrop her conversations with her mother, to always know what she is doing, to know how well she is all the time.
There's no appreciation for me being around, even more so, saying that you don't matter that much, and what do even have or experienced together to be close. And that she can't really be close to people that don't immediately say what they're thinking (like me, she said, even though when i asked if she thinks I'm a fake friend she said no but I'm not honest), but part of me feels that it's bullshit, everyone hides something and only lets a part of themselves out, although it's true that sometimes I act more quietly and like I'm obviously hiding something. I feel inadequate and really bad because of that because the things I experienced in the last months were big for ME, and definitely changed me, but I guess they were nothing to her.
Sometimes she talks about how it's weird to her that normal people have dreams about having homes, vacations etc. One time she said how when she was little she said she never would be boring and bitter like adults, and then depression hit her. Recently she said she finally has a dream, to be able to rent a studio apartment to finally live alone. It kinda affected me, because I DO live with her (apart from others), and that would mean that she wants to get out from me too. One time she said that she hopes someone lively and fun will move in with us once our current flatmate get out, and that would mean that she is bored with me and my character, and she much preferred the previous one.
With the whole moving out thing, she sometimes talks about things getting better, like closer to spring she will renew the gym subscription, we will decorate the balcony for parties and hanging out (of course she said something about sleeping drunk in there...), and generally some things like that. It does make me wonder, do those lower points happen especially in autumn/winter ? I mean, I know there's even a disorder for that but I can't imagine there being such a huge difference.
When she started school, she became really overwhelmed with the amount of exercises she had to do before lessons. Most teachers don't have everything done beforehand but she said she absolutely needs to, and because of that she spent most of the time just doing them or resting, she was so obsessed with doing them she wanted drop out of our mountain vacation trip because she would be too much behind, and she got angry at me for saying that she needs a rest and that my talking doesn't help anything.
Over a month after the school she started the meds, and it doesn't feel like they helped her, at the beginning they only made her really sleepy and out of energy. In some ways i think that they made her worse, or maybe she just didn't have the energy to hide some things. I remember her reading the drug leaflet and noticing loudly that it may strengthen suicidal thoughts, i then read it myself because I was worried. It's honestly a bad thing that she had to check with the psychiatrist only after 2 months and not sooner because it wasn't helping her. On the second visit the doctor was surprised that it didn't help her (which I think might be a bad thing from her since it reinforces the thought that nothing will help her), and decided to up the dose for next 3 weeks to rule out the drug, and mentioned another stronger drug that she will prescribe her, and Amy asked her is it's a drug that is used in a psychiatric hospitals because she wanted to know, and apparently yes. I'm kinda scared what might be happening when she starts it, because the upped dose of current one doesn't seem to change anything. One time she asked me if I think they could lock her up if she caused an accident while driving while on this drug (if its not allowed to drive on it, because she admitted she would anyway), which again messed with my head a lot. The doctor also said that she might be more immune to various drugs than most people, and she said that it's probably true because a lot of the drugs she takes are quite strong, and she takes A LOT of them, hormones for acne and her very strong and long periods, inhaled steroids for asthma, antidepressants, drugs for sleep. Sometimes she ignores signs of some of her illnesses, like anemia. She sometimes offers people prescription drugs like antidepressants or antibiotics, which makes me really angry because those shouldn't be given around like candies, but like I said earlier I never told her it makes me angry. She also said that she only counts on the meds to work, if they won't, she would off herself
I joked a few times that we could get a cat here, I know that it's no cure but animals can certainly be a help for people who are going through rough times. She really took the subject seriously some day and convinced everyone, including our tenant and flatmates, that we should get a cat. She really wanted to have this one specific cat about 2h hour drive from us, so we drove there, but the cat got away from our car, and we couldn't find it. Few hours later when we got home she was convinced that we killed that cat and started asking everyone if they want anyone dead, because she can arrange that, because everyone around her dies, and she didn't want any cat at all anymore. But we eventually took Luna, and the missing cat was found later. After a few weeks with the cat, our flatmates started complaining about about the cat being in the apartment and not only our rooms (WTF?) and about its litter box and food. Amy was already really annoyed by them, especially this guy who is a little dumb, talkative and annoying, but this whole situation took it too whole another level. She almost couldn't control herself with how much they got on her nerves, merely hearing them walk on the corridor would make her furious. One night in the middle of the week she started going to the kitchen to get drunk to be able to sleep because of them. I obviously couldn't ignore that so I went with her to just be there. She changed topics every few seconds, talked about something that its a good thing our knifes are not sharp, she was generally acting very ill, which usually makes me extremely anxious and quiet. I feel like she was noticing that and she said "why aren't you talking with me ? X and Y always had gossips with me in the kitchen...". Then she went to sleep, texted me a lot about 100 different topics, and then went back to drink some more, then when she went to sleep she texted me something that made me feel like my brain is being fried. She send me a receipt of her drug and it said that overdosing it might cause heart problems and even death, and she added "if I found out that suicide is not a sin, or something changes, I already know the way <3". I didn't know what to do with myself for a good few minutes. My mind was racing and frying, my heart was frozen, and it took me a good while to calm down. Eventually I just took our cat and took it to her to sleep with, but didn't bring the subject, I just couldn't, I was too weak.
Next day she started being obsessed with moving out of here, far away from them, she started looking for available apartments and firstly I wanted to move with her, but the more I thought about this, the more I thought I just couldn't handle all of these things mentally. She was pushing me to define my stand on this, and just said "fuck it" angry at me for not being decisive," I'm gonna move with another guy I know", but I don't think that worked out since she eventually started looking for studio apartments for herself. Eventually I went to her and said that I think I want to live alone, that i feel kinda unstable mentally myself, and I wanted to let her know that I'm not wanting to let her go, but she was just like coldly "I'll be fine" without much emotion behind that. I then started to pour out my things about her (at first she said she didn't have the energy for that, but asked her to listen), how sometimes I felt like she has something negative about me that she doesn't tell me, that's she's colder to me than usually, she said that she's like that to everyone now, and I said that I felt like it was more personal, and she denied. I asked her if she thinks that I'm fake and she said "not fake, but you're not telling what you're thinking" and that she couldn't be close with people like that (or something along those lines). She said that I should have told her all of that right then. She always prides herself for always saying exactly what she means and being painfully straightforward. I also tried to confront her about being negative about my therapy, because I said to her I went to therapy, and she said "and you think it will help you ?" kinda ironically, and i was really hurt by that, she doesn't really believe in therapy and said that judging by colleges in our country her mother is a better therapist than most Ts here. She said then that she meant if I THINK its going to help me, not mocking, and when I said that I don't respond to "how was it?" is because I was worried she would mock me, she replied with "whatever , if you say so". I also said that I'm secretive because telling the truth would make other people hurt me, and she said "well of course".
To this day I don't know if I hurt her with that conversation, I'm not even sure if she understood that I'm very bad mentally right now mainly because of her. I felt really guilty about abandoning her, and talked about it extensively on a therapy session. I know that to save anyone you have to save yourself first, but I would be just proving that she's fucked up and everyone will eventually abandon her. On the other hand, I don't know if she cares AT ALL about me leaving her, maybe I really do am just a flatmate and not much else anymore.
Her mood massively affects mine, I could have the best day of my life and one sentence from her could easily ruin that. Sometimes I get anxious when I hear her walking on the corridor or when she gets back from school because I have no idea what mood she might come home with.
Most fucked up thing is that despite all of this is sometimes I'm still attracted to her. All it takes is one smile, one good day and I'm still rethinking if I would ever want to be with her. And there are also very good reasons for that, she can be very caring, lovable, funny and clever. I also fantasize about her sexually to some small extent. And the thing is that I never before found her very attractive and wasn't interested in her.
How does her mother fit in this ? I don't know but she lost her father as a child, she was taking her to therapists and psychiatrists since she was a child . Sometimes I feel like she can make her worse by saying certain things, like when missing cat was found and saying that it was bad and scary and that we could be taking this one right now. She might have been very overprotective (or might have good reasons to) but Amy was being rebellious and reckless anyway, which might have caused how many lies she tells to her.
When it comes to me, I've never been in such a bad state mentally, today is not the worst but the general period is without a doubt the worst time of my life. Even before all of this I was SURE I needed some help with my mental health, but everything that was happening, her darkness sipping into me, triggering me, listening and talking about suicide all the time for literal months can't be good for anyone although I think I try to show her it doesn't affect me that much, me internally reacting very very badly to her strange and sometimes deranged and reckless behaviours, feeling on the edge a lot of the time due to her, not being able to think about anything else, all that made me finally take the step and make an appointment with a therapist. I noticed in myself symptoms of depression, social anxiety and ADHD, I'm still not sure if I would be diagnosed with anything but I do know that something is wrong with me, especially since others don't seem to be so deeply affected by her despite being close to her for longer than me. There were days where I couldn't sleep, in which I had a strong feelings of hopelessness, depressing feelings about her, myself, my life and the whole world, I researched a lot about depression, and some places are really bad to get into because there is no hope in there, people just drag each other down and write that nothing ever worked for them etc. I even thought about reading up about some therapeutic techniques I could use on her, but now I notice how stupid that sounds.
I sometimes think if she realizes how difficult it is to listen to some of the things she says and does. And I'm not talking about her being difficult and with a quick temper, but just genuinely pouring this darkness on those close to her.
In terms of therapy, I'm still not sure if it can help me with anything. I'm not discounting the people that it did help, but I'm just not sure about me. I know that it probably takes time, I do genuinely feel better when someone listens to all of that (even if I feel like a fraud sometimes because there are surely others that come to her with heavier stuff) even if it lasts only some time after the session. I'm not even sure what would therapy do to me, like what exactly could it possibly change about me, will I care less, will I just cope better, will I change my personality, or will it just be something that I can tell myself that I'm doing without actually helping me
That's a weird one, I'm kind of angry at her for being the best or at least very good at a lot of things, that (when she wants to of course) she can befriend literally everyone and people adore her (like the kids in school, parents congratulating and being shocked how great the kids are doing at school), she had a lot of boyfriends and always seem to have some guys trying to get to her. She's shockingly charismatic, talkative and social when she wants or needs to be. I'm always complaining about not having friends and then she scoffs at me for that I don't know what I'm talking about, but I don't interact with 10% amount of people she does even though she ALWAYS ALWAYS talks how antisocial and what a b she is (meaning she's mean to everyone), she knows a shit ton of people, shocking number actually, especially when you think about her mental state
I really try to be a good friend, but that seems to not be enough. I try to help her with everything, doing the shopping, being with her and talking, asking how she feels, figuring out ways to maybe not help but at least show the support.
Right now we're still gonna live together and I'm gonna move in to the bigger room, and I plan to be in our hometown working remotely more to be better mentally, but I'm still unsure how all that is gonna work out...
Sometimes I feel like I'm fluctuating with how much this really affects me, It feels random, some moments I think all of it affects me less and am able to just go somewhere else with my thoughts, but not always.
==== 6 months later====
Some time has passed since I wrote those last paragraphs, actually it's already 6 months, and in some ways things are better, but in some they are much worse. She got better, not all the way she was before, she still hates being with people and is very mean, sarcastic and emotionally careless (she recently found out she'll probably won't be able to have kids and it didn't faze her at all), throws a joke or two about suicide but it doesn't seem so serious now, she got off meds as far as I know (because I don't know much anymore, but I'll get to that), she found a psychiatrist that first wants to make all kind of tests before prescribing her any drugs, she actually talks about plans for the future, is able to cook for herself, is more social, she's even going to a wedding with a friend she almost hooked up with a month ago (that's also a big thing that for me I want to write about later).
As for me, I'm much worse in a few ways. These things she said and did affected me very deeply back then and I wanted a way to cope with that, and I started to call my old friend Jane and tell her some of the situations that were happening here. I felt bad about it but I just couldn't help myself, I had to tell someone. That was before I got my therapist, and I'm mainly talking about everything with her now, but I was so caught up and messed up with everything, that even after starting the therapy I also talked about some of the things with my ex who is still my good friend, I mentioned she has depression and takes meds to one of my colleagues (without any details), and I mentioned that she has some problems and thinks about moving out to another friend, one day I also told everything to my parents (without the most disturbing details) because I was on a verge of a mental breakdown and just couldn't bring myself to come back here. I also once told our new roommate that Amy is very weird and obsessed about some things like loudly closing doors etc. without telling much else though. That's a lot of people and honestly I don't trust myself that I didn't say anything else to anyone although I doubt it as I don't have much friends or interact with people a lot. Not that it excuses me, but she wasn't really too secretive about it and seemed very open to talking about being depressed and hating life etc. I certainly broke her trust and I feel like shit for it, nothing really excuses me and I can't change what I did, which is slowly killing me inside.
She confronted me about it when I came back from my parent house after telling them everything and finally got the courage to text her about the way she treats me, about what I did wrong, if she thinks that I'm hiding something from her or that I'm insincere about everything I do. Because she's very different to me than she was before and it honestly kills me inside. She told me she regurarly catches me lying about irrelevant small things and she has no idea why but recently she doesn't even trust herself, let alone someone else. I don't think I ever deliberately lied to her but I might have unknowningly responded with wrong information so she doesn't get mad ex. who didn't do the dishes or something. The worse thing is that she said that she heard things, certain minor details about herself from people that should know absolutely nothing about her, and she doesn't want anyone to know anything about her. Of course she didn't specify what details (and if they were even something private, but I can only assume yes by her reaction) and what people (to not break their trust) and I've been thinking about it ever since. She said that I was never her friend, I never knew anything about her and she doesn't really consider anyone her friend since O died from cancer. And that you can't just take anyone from the street and befriend them, and that we can just normally live our lives separately and not get too involved with each other, which really, really fucking hurt me to hear from person that I cared so deeply for, that I tried so hard to show that she matters to me, and to which I gave up so much of my own mental wellbeing to the point of feeling mentally ill myself (at least much more than usual).
I of course haven't told a word anyone since that conversation, and not because I was scared someone might tell her again, but I realize what a huge mistake that was and I honestly hate myself more than ever for breaking her trust and being such a piece of shit and not being able to change what happened or even to make up for it.
Our relationship gets kinda better at times, she talks to me normally sometimes mainly about our cat, although never for too long and practically never initiates a conversation, she barely texts with me, ignores me a lot, she doesn't really talk to me about what is happening with her life and work etc. I mostly find out anything from her conversations with others when I'm present, she is a lot more social with her friends recently and when she sends some screenshoted memes on a group chat there's always someone she's texting with, she's online a lot despite not writing me back, she goes out drinking with her friends every few weeks and I'm never a part of it anymore, I never drive with her back to our town on weekends anymore, and all of that while she live behind a wall, and this actually real rejection is quite honestly making me feel actually suicidal at times, and it gets worse with time to the point that I'm worried I might do something to myself, maybe not now or soon, but in the future, and I even sometimes write vague scenarios in my head about it. Apart from still going to therapy (which still doesn't seem to help me) I signed myself up to a psychiatrist despite my therapist saying that she doesn't see anything clinical in me, with the main issue being an ADHD diagnosis, as that's what I thought most accurately explains my struggles (especially RSD), and I did get diagnosed but I feel like I might have bended the reality a little and not actually have it, I am on my 2 days of meds (upped the dose today) and don't really feel much apart from a very light headache and dry mouth, so I guess that won't fix me after all.
When we were on a mountain trip a month ago I was feeling very bad, because while I was still a part of it and went with everyone, she treated everyone completely different to me, she was laughing, joking with them, being nice and talking to and being interested in them, and the others are not really my close friends so I was feeling a bit alone and isolated. The last night of the trip she and one of the guys (the one with which she's going to the wedding) went for a walk in the middle of nowhere together completely drunk, pissing everyone off for being irresponsible. But while everyone was scared and angry, I was depressed and I guess suicidal, I still have feelings for her despite everything, and seeing that she can go out into the night kissing some guy and after everything can't even hold a conversation with me or tell me anything nice was honestly doing very bad things to my head. And I remembered when a year ago she said she can't be with me, she's too fucked up and couldn't do that to me, but she knows this guy for almost 2 years now and considers him a colleague too so how's that different? I don't even smoke but I smoked like a whole pack of cigarettes that night...
When we came back from the trip I was in a very bad place mentally and said that I wanted to talk, I told her that I can't do this anymore and that I can't control the envy that I feel and that I'll probably have to move out even though I don't want that, and I don't want to leave her alone with our cat, she gave me an impression that she wants me to try, she mentioned my ex that's still my friend and that I got over her, and I told her it took me literal years to get over her, and she said that "so it's possible", we talked some more, maybe the most we talked in weeks if not months about various things, and I felt that things were going to get better, But they didn't. A few weeks passed and I feel just as rejected as before.
I can't disinvest emotionally from her, I can't stop thinking about what she thinks of me, if I'm fake and dishonest and always hide my true motives, and I don't think there is a point in confronting her again and apologizing and hoping for forgiveness, I feel like current state of my life will never change and even if we stop seeing and living with each other anymore, it will still take me years (if ever) to get over everything that happened in the last year because I'm not really better mentally when I'm home with my parents, I still think about it all the time. I don't want to leave this place, and I don't want to leave her with a cat she'll have to take care on her own, I don't know what to do anymore.

Before I list these I want to say that just because I find these games almost perfect doesn't mean they're all my favorite games of all time. Most of my favorite games are admittedly extremely flawed however replay value is very important to me over perfected aspects.

1. The Last of Us
2. Shadow of the Colossus
3. Demon's Souls
4. Resident Evil 7
5. Mafia Definitive Edition
6. GTA 4
7. Super Mario Bros. 3
8. Sekiro
9. Resident Evil 4 (2023)
10. LittleBigPlanet 2
11. God of War 3
12. Batman: Arkham City
13. Castlevania: Symphony of the Night
14. Portal 2
15. Braid
16. Super Mario World
17. God of War 2
18. Final Fantasy 7 (1997)
19. Donkey Kong Country
20. Sly Cooper 3: Honor Among Thieves

Gene therapy has to be one of the fastest-growing segments in modern medicine amid increased focus on developing life-changing therapies for cancer and diabetes.
Genprex Inc (NASDAQ: GNPX) is one of the few clinical stage companies offering exciting investment opportunities in a segment growing at a compound annual growth rate of 19.1%.
It is one of the few plays trading at highly discounted levels while developing therapies and technologies for treating a range of disorders, such as inherited diseases and cancers. Rather than treating patients with drugs or surgeries, Genprex is working on therapies that insert genes into a cell to cure various diseases caused by genetic variants. Gene therapies stand out partly because they are one-time events, although there might be additional dosages.
With the Gene therapy market expected to grow to $29.47 billion from $7.54 billion in 2022, there is every reason to be bullish about Genprex's growth metrics and long-term prospects.
Here are a few reasons why Genprex should be on your watchlist.
TOP GNPX HIGHLIGHTS
• GNPX stock is trading near a 52-week low with RSI near 46 - A strong bounce can happen ANYTIME
• Dawson James has a Buy rating on the stock and an average price target of $5.61 - representing over 500% upside potential from current levels.
• Genprex is home to some of the best technologies designed to administer disease-fighting genes most effectively.
• Genprex has made impressive strides in developing REQORSA, its novel treatment for lung cancer.
• With the Gene therapy market expected to grow to $29.47 billion from $7.54 billion in 2022, there is every reason to be bullish about Genprex's growth metrics and long-term prospects.
Robust Gene Therapy Technologies
Genprex (GNPX) is home to some of the best technologies designed to administer disease-fighting genes most effectively. As a result, its technologies have the potential to provide new breakthrough therapies for large patient populations struggling with cancer and diabetes.
Nanoparticle Delivery System is the first systemic gene therapy delivery platform that can be used to enclose plasmids that deliver tumor suppressor genes. It also administers encapsulated plasmids which are taken up by tumor cells and express any missing proteins in the tumor cells.
In addition, the company has REQORSA, a leading immunogen therapy drug for non-small cell lung cancer. The therapy is administered through the company's systemic gene therapy platform for cancer.
Finally, Genprex boasts of game-changing GPX-002, a diabetes gene therapy comprising a novel infusion process. It relies on an endoscope and adeno-associated virus vector to deliver Pdx1 and Mafia to the pancreas.
Lung Cancer Treatment
REQORSA is the company's lead candidate drug currently in clinical trials for the treatment of non-small cell lung cancer and small cell lung cancer. The novel treatment positions Genprex to be a key player in treating lung cancer, the leading cause of death worldwide. Lung cancer causes more deaths than colorectal, breast, liver and stomach cancer. With the limited benefit from current therapies, Genprex novel candidate drug has what it takes to address the unmet medical need, more so in lung cancer patients.
After successful clinical trials, the candidate drug has already received fast-track designation from the Food and Drug Administration. In a recent Acclaim-1 phase, ½ clinical trial REQORSA, combined with tagrisso(R) (osimertinib) for treating small cell lung cancer, was well tolerated with no dose-limiting toxicities. The Safety Review Committee has already approved continuation into phase 2 expansion. A combination of REQORSA and Osimertinib has already received Fast Track designation from the FDA for use in the Acclaim-1 patient population.
Genprex (GNPX) is already conducting preclinical research as it looks to explore REQORSA's potential use in other solid tumors. It is also exploring how other cancer-fighting genes can be used on its non-viral gene therapy platform.
Multidisciplinary Management Team
Genprex's (GNPX) long-term prospects are further affirmed by its multidisciplinary team of executives and advisors. The broad business experience in biotech and pharmaceutical that the team brings should allow the company to accelerate the development of its novel treatment for lung cancer and address the significant unmet medical need.
The management team boasts of highly experienced personnel as part of its scientific advisory board that reviews research and development activities and provides recommendations to accelerate the development of the moving treatment. There is also a clinical advisory board tasked with overseeing clinical trials to ensure they are up to board or approval by the FDA.
Why Genprex (GNPX) Stock is a Buy Now
Genprex (GNPX) is among the few gems in gene therapy trading at highly discounted levels. With a market cap of about $41 million, the company is highly undervalued, given the milestones made in developing revolutionary technologies for administering disease-fighting genes in the fight against cancer and diabetes.
In addition, the company has made impressive strides in developing REQORSA, its novel treatment for lung cancer. The treatment achieving fast-track designation from the FDA affirms how prospective the candidate therapy is in addressing one of the biggest unmet medical needs.
Strategists in Wall Street have already taken note of the company's long-term prospects, with Dawson James initiating coverage of the stock with a Buy rating. In addition, the stock boasts an average price target of $5.61, representing over 500% upside potential from current levels.
While insiders own about 4.5% of GNPX, their interests are perfectly aligned with that of investors. Likewise, institutions owning about 7.8% of the stock underscore the strong belief in the company's gene therapy pipeline.
In the near term, the investment community could elevate the value of GNPX closer to that of its peers.
If you need more info,
Then you can view a really detailed report out HERE.

Before I list these I want to say that just because I find these games almost perfect doesn't mean they're all my favorite games of all time. Most of my favorite games are admittedly extremely flawed however replay value is very important to me over perfected aspects.

1. The Last of Us
2. Shadow of the Colossus
3. Demon's Souls
4. Resident Evil 7
5. Mafia Definitive Edition
6. GTA 4
7. Super Mario Bros. 3
8. Sekiro
9. Resident Evil 4 (2023)
10. LittleBigPlanet 2
11. God of War 3
12. Batman: Arkham City
13. Castlevania: Symphony of the Night
14. Portal 2
15. Braid
16. Super Mario World
17. God of War 2
18. Final Fantasy 7 (1997)
19. Donkey Kong Country
20. Sly Cooper 3: Honor Among Thieves

The thing I dislike the most about the update is that accolades being gone removes a big part of the excitement and reward for winning a match.
Blood Bonds (and the things you can buy with them) are the only thing that's there to stay. Earning a couple BBs from an extraction adds a lot to the experience, because you know you won't lose them by dying in mission or prestigeing. They give a sense of permanence to your success that won't just get wiped by a couple of "Hunt taketh" kinda matches. Not to mention that slowly racking up BBs for that skin you wanted is an engaging and satisfying overarching progression system.
No, that does not mean I only play to get skins. It means having a meaningful reward for winning added a lot of spice to the experience, which is now made much blander because Hunt Dollars aren't really a reward when you can get them from a billion different sources now. Also, if there's anything that is worth rewarding in a PvP game, it's killing other players and extracting imo, not running around killing AI with fire ammo.
Weeklies reward you as well, but they do so by making you go out of your way to do it. They are essentially busywork, whereas accolades are very naturally implemented into the core gameplay, and reward success and good performance. Not to mention that Questlines and now also Battle passes work on the same system, which not only makes challenges super redundant, but further disconnects the rewards from the core gameplay loop.
I get that the whole point of this was reducing BBs earnable for free, but I think accolades sould be the last thing to go on the chopping block. There are ways to nerf them without completely detracting from the satisfaction of the reward. Like, award them only for bounty extractions, for amount of kills, idk, something that ties into the PvP nature of Hunt and encourages players to play the objectives.
Just my two BBs on the matter.
TL;DR: Accolades are a great reward for winning, and it makes no sense they get the axe first before less satisfying systems like weeklies, dark tribute etc.

The updated bracket is here.
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Yesterday's match-up was definitely a tough one for a couple of fan favorites, but it looks like Ethan beating up Jack is more exciting for the group than Henry Gale's debut as All The Best Cowboys Have Daddy Issues advances.
​
Today? Today is most likely a blowout, I'm not going to lie. An iconic Season 1 episode against an early Season 3 episode generally spells doom for the latter. But there's always the possibility I'll be proven wrong on that. Synopses are below:
​
"Do No Harm" is the 20th episode of Season 1. Jack and Sun work to save Boone while Kate is sent to retrieve Sawyer's alcohol for sterilization. On the way back, she runs into a clearly-in-labor Claire. She calls for help, Jin hears her, and is given the alcohol to take to Jack. Kate stays and helps Claire deliver Aaron, while Jack gives his greatest efforts to save Boone, ultimately having Sun try to stop him from giving his own blood to save Boone, and only giving up when Boone tells him he can let him go. In flashback, we see the events surrounding Jack's wedding to Sarah, where he tells her that she saved him, not the other way around. On island, after Boone's death, Jack vows to go after and confront Locke.
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"The Glass Ballerina" is the second episode of Season 3. In flashback, we see Sun having an affair with Jae Lee, which Mr. Paik has found out about. Paik sends Jin to take care of the problem, but does not tell Jin what he knows. Jin beats up Jae Lee and tells him to leave and go to America, to never show his face there again. Jae instead relents, committing suicide by jumping off the balcony of the hotel room. On island, we get more of Jack in an aquarium (Where Ben shows him footage of the Red Sox winning the World Series), Sawyer and Kate in the cages and their work in the quarry, and Sun, Jin, and Sayid on the boat. Sun, Jin, and Sayid find a decoy village and are confronted by The Others, leading to Colleen being shot and their boat being taken.
​
So which one gets your vote?
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Poll Link: Do No Harm VS The Glass Ballerina

She's a forensic doctor in the 21st century, but she unexpectedly became a lady at the Prime Minister's palace who is at death's door. It is said that her medical skills are not good which caused the death of the general's son, and thus the emperor wants to kill her to avenge the general! They said she's arrogant and despotic, hated by all, and her family wants to cut ties with her! She's said to ... Read The Cold King’S Beloved Forensic Wife - Chapter 35 - MangaPuma. Read more at https://mangapuma.com/the-cold-kings-beloved-forensic-wife/chapter-35